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pentobarbital will minimize the level or impact of nilotinib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.pentobarbital boosts effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use Caution/Keep track of. Coadministration of ifosfamide with CYP2B6 inducers may well increase metabolism of ifosfamide